Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Balasubramanian, M. P.
- Protective Effect of Adhatoda vasica on D-galactosamine Induced Liver Damage in Rats with Reference to Lipid Peroxidation and Antioxidant Status
Abstract Views :537 |
PDF Views:457
Authors
T. Jayakumar
,
M. Ilayaraja
,
M. P. Sridhar
,
S. Sivalokanathan
,
T. R. Bharth Prasad
,
M. P. Balasubramanian
Source
Journal of Natural Remedies, Vol 9, No 1 (2009), Pagination: 91-98Abstract
The present investigation was carried out to evaluate the lipid peroxidation and antioxidant nature of aqueous extract of Adhatoda vasica (AEAV) on D-galactosamine (D-GalN) induced hepatic damage in wistar albino rats. Hepatic damage was induced by intraperitonial injection of DGalN (500 mg/kg, bw) for 2 days. AEAV extract (350 mg/kg, bw) was given orally for 21 days before the induction of hepatic damage. The levels of lipid peroxides (LPO) under basal and also in the presence of inducers (H2O2, ascorbate and FeSO4) were estimated in liver of control and experimental animals. enzymic such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants like glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and total thiols (TSH) levels were determined in all the groups of animals. A significant increase in LPO levels were observed while the levels of enzymic and non-enzymic antioxidant were decreased, in D-GalN induced rats. These altered enzyme levels were ameliorated significantly in AEAV pretreated animals. This protective effect of AEAV was associated with inhibition of LPO induced by D-GalN and to maintain the antioxidant enzyme levels. From this study it is concluded that the pre-treatment of AEAV has an antioxidant activity against D-GalN induced hepatic damage.Keywords
D-galactosamine, Adhatoda Vasica, Lipid Peroxidation, Antioxidants Enzymes, Liver Damage- Effect of Naphthalene on Lactate and Pyruvate of a Marine Edible Crab Scylla serrata
Abstract Views :167 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani Campus, Chennai 600 113, IN
1 Department of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani Campus, Chennai 600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 35-35Abstract
The effect of Naphthalene on lactic acid and pyruvic acid was studied in ovary of the crab Scylla serrata with reference to ovarian maturation. The ovarian lactic and pyruvic acid level of Scylla serrata when reared in naphthalene free medium was 48.66, 67.33,90.66,75.99 and 43.99 μg/100mg wet tissue and 5.52,5.60,10.92,8.33,6.66 and 6.51 mg/100mg wet tissue at stage I, II, III, IV, V and VI ovary respectively. Both lactate and pyruvate were increased in all ovarian stages when crabs reared in 0.20mg/litre naphthalene concentration.- Effect of Mercury and Naphthalene on Non-Specific Esterases and Lactate Dehydrogenase Activity during the Vitellogenic Stage of the Marine Edible Crab Scylla serrata
Abstract Views :220 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology and Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, IN
1 Department of Pharmacology and Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 58-58Abstract
Generally, the reproductive tissues are the main targets for any environmental pollutants. In crustaceans pollutants accumulate in lipid rich yolk, the contents of which are mobilized in organ formation during larval development. The crabs were reared in individual and combined concentrations i.e. 10 mg of mercury, 100 mg of naphthalene and 10 mg of mercury with 100 mg of naphthalene for 96 hrs. The effects of mercury and naphthalene on the non-specific esterases and lactate dehydrogenase have been studied in muscle, hepatopancreas, ovary and haemolymph of a marine edible crab Scylla serrata, with reference to ovarian maturation.- Toxicity of Combination of Zinc Sulphate and Aluminium Chloride to a Marine Edible Crab Scylla serrata
Abstract Views :200 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology & Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, IN
1 Department of Pharmacology & Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, IN